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Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.
Zhang X, Luo M, Dastagir SR, Nixon M, Khamhoung A, Schmidt A, Lee A, Subbiah N, McLaughlin DC, Moore CL, Gribble M, Bayhi N, Amin V, Pepi R, Pawar S, Lyford TJ, Soman V, Mellen J, Carpenter CL, Turka LA, Wickham TJ, Chen TF. Zhang X, et al. Among authors: mclaughlin dc. Nat Commun. 2021 May 11;12(1):2637. doi: 10.1038/s41467-021-22898-3. Nat Commun. 2021. PMID: 33976146 Free PMC article.
Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15.
McArdel SL, Dugast AS, Hoover ME, Bollampalli A, Hong E, Castano Z, Leonard SC, Pawar S, Mellen J, Muriuki K, McLaughlin DC, Bayhi N, Carpenter CL, Turka LA, Wickham TJ, Elloul S. McArdel SL, et al. Among authors: mclaughlin dc. Cancer Immunol Immunother. 2021 Sep;70(9):2701-2719. doi: 10.1007/s00262-021-03001-7. Epub 2021 Jul 9. Cancer Immunol Immunother. 2021. PMID: 34244816 Free PMC article.
Structures of adnectin/protein complexes reveal an expanded binding footprint.
Ramamurthy V, Krystek SR Jr, Bush A, Wei A, Emanuel SL, Das Gupta R, Janjua A, Cheng L, Murdock M, Abramczyk B, Cohen D, Lin Z, Morin P, Davis JH, Dabritz M, McLaughlin DC, Russo KA, Chao G, Wright MC, Jenny VA, Engle LJ, Furfine E, Sheriff S. Ramamurthy V, et al. Among authors: mclaughlin dc. Structure. 2012 Feb 8;20(2):259-69. doi: 10.1016/j.str.2011.11.016. Structure. 2012. PMID: 22325775 Free article.